Overview
I am interesting in applying bioinformatics, chemoinformatics, pharmacoinformatics, toxicoinformatics, and clinical/translational informatics to a broad range of topics, namely drug discovery in various diseases, drug metabolism/pharmacokinetics, and clinical studies.
Technology
Two invented new approaches have been extensively to my current investigations, namely pharmaocophore ensemble/support vector machine (PhE/SVM) and hierarchical support vector regression (HSVR). The formed was devised to take into account the promiscuous nature of target protein and the later was created to eliminate the compromise between local model and global model. More schemes are being developed to cope with perplexing problems in life science and clinicology.
Current Topics
ADME/Tox
We have been deriving a variety of in silico models to predict the absorption, distribution, metabolism, excretion/elimination, and toxicity (ADME/Tox) profiles of pharmaceuticals, which are of critical importance in drug discovery and development and play a major role in attrition.
Neurodegenerative Diseases
This is a collaborative investigation to target a specific enzyme, which plays a critical role in various neurodegenerative diseases. We are taking in silico approach in conjunction with experiments.
Clinical Study
Our group and Prof. Weng's group are collaborating with Mennonite Christian Hospital to develop theoretical models to predict the onset of some disease in the hope of providing more accurate clinical diagnosis to benefit patients.
We have been deriving a variety of in silico models to predict the absorption, distribution, metabolism, excretion/elimination, and toxicity (ADME/Tox) profiles of pharmaceuticals, which are of critical importance in drug discovery and development and play a major role in attrition.
Neurodegenerative Diseases
This is a collaborative investigation to target a specific enzyme, which plays a critical role in various neurodegenerative diseases. We are taking in silico approach in conjunction with experiments.
Clinical Study
Our group and Prof. Weng's group are collaborating with Mennonite Christian Hospital to develop theoretical models to predict the onset of some disease in the hope of providing more accurate clinical diagnosis to benefit patients.
